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Mechano Growth Factor

MGF has been shown to:
  • boost the ability of wasted tissue to grow.
  • activate muscle stem cells.
  • increase the upregulation of protein synthesis.
  • induce rapid muscle hypertrophy.
  • considerable potential as a generic means of treating muscle cachexia.

After resistance exercise, IGF-1 is released within the muscle. Specifically, at this time, immediately following the mechanical use of a muscle, the IGF-I gene is spliced towards MGF which initiates hypertrophy and repair of local muscle damage. It does so both by activating muscle stem cells and satellite cells, but also via various other anabolic processes. It differs from "regular" IGF-1 mainly due to it’s C-Terminal sequence.


Loss of muscle mass (sarcopenia) is one of the main problems associated with ageing as it has major health care as well as socioeconomic implications. The growth hormone (GH)/IGF-I axis is regarded as an important regulator of muscle mass. However, it is now appreciated that other tissues in addition to the liver express IGF-I and that there are local as well as systemic forms of IGF-I which have different functions. After resistance exercise, the IGF-I gene is spliced towards MGF that kick starts hypertrophy and repair of local muscle damage by activating the muscle stem cells as well as anabolic processes. Interestingly, loss of muscle mass in old age and in certain diseases is associated with an impaired ability to express MGF.

Bodybuilders and athletes have been experimenting with MGF for a couple of years already. It was first discovered in the muscle by Goldspink, et al. In human muscle, a 49-base insert changes the reading frame in mechano growth factor (MGF) as compared to IGF-1.

Bodybuilders and athletes have been experimenting with MGF for a couple of years already. It was first discovered in the muscle by Goldspink, et al. In human muscle, a 49-base insert changes the reading frame in mechano growth factor (MGF) as compared to IGF-1.

What is does

When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing of IGF-1 into MGF, production then switches towards producing a systemic release of IGF-1Ea from the liver, which also upregulates protein synthesis as well. The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary anabolic mechanism by which the body produces new muscle. MGF is available as an injectable peptide, and it has been anecdotally shown that injecting it will cause a response in the area resulting in localized muscle growth.

Product Information
  • Pre-diluted injectable -10mg @ 2000mcg/ml in 5ml vial
    20mg @ 2000mcg/ml in 2 x 5ml vials

*Note: If you are a registered professional athlete please consult the ASADA or WADA guidelines and your coach, club and/or sporting body before using this peptide.