Due to Hexarelin's ability to increase secretion of natural Growth Hormone, most of its effects are similar to those of synthetic GH, although to a slightly lesser extent. Hexarelin (HEX) is a peptide GH secretagogue, structurally similar to GHRP-6, in the growth factor family which stimulates the release of growth hormone (GH). It can be used medically to treat GH deficiency.
There is no appetite boost with Hexarelin use due to its inability to drastically increase Ghrelin levels that are responsible for added hunger and quicker gastric emptying.
In studies where Hexarelin was injected subcutaneously, Growth Hormone, measured through plasma concentrations, increased significantly and within 30 mins of injection. GH levels decreased back to normal around 4 hrs post injection. The GH increase, was found to be effective up to 2mg/kg, any further increase in dose was found to be ineffective in causing a GH response.
Results showed that Hexarelin’s effect on GH stimulation tapered between weeks 4 through 16. Separating cycles by 4 week off periods, avoided the negative feedback loop and the next cycle of Hexarelin produced the same level of results as the first cycle.
Hexarelin, administered subcutaneously produces a dose-dependent GH response from the Pituitary.
The advantages of having HGH secreted in larger amounts in the body would be similar to what happens when injectable growth hormone is administered. Effects from GH include increased bone mineral density, increased mitosis and meiosis which leads to more muscle mass, triglyceride hydrolysis which causes prominent fat loss, connective tissue strengthening, and improved skin elasticity.
GH secretion also leads to the liver secreting more IGF-1 (Insulin-Like Growth Factor One), which by itself has a host of effects similar to GH. Users of IGF-1 typically experience increased strength and muscle mass, as well as a very pronounced fat loss.
Hexarelin will give an experience and effect of both Growth Hormone as well as IGF-1. However, since Hexarelin actually stimulates the body to produce more GH, it may be likely that the eventual shutdown of the body’s natural GH production may be avoided, as is seen with injectable GH. For this reason, many athletes use Hexarelin alone, but others have used it after a Growth Hormone or Insulin-Like Growth Factor one cycle, to "jump start" their own natural GH and IGF-1 production. Of course, as we know from other peptides like GHRP-6, this type of surge in Growth Hormone levels has been positively correlated with increases in strength, muscle hypertrophy, and fat loss. Therefore, the many advantages of having GH secreted in larger amounts via administration of Hexarelin are comparable to the effects of injectable growth hormone administration.
Hexarelin enhanced GH secretion also leads to the liver secreting more IGF-1(thought to be the primary causative factor in the anabolic effects of Growth Hormone).
*Note: If you are a registered professional athlete please consult the ASADA or WADA guidelines and your coach, club and/or sporting body before using this peptide.